Adenosine 3′,5′-cyclic Monophosphate, 8-Bromo-, Sodium Salt,10MG,203800-10MGCN,Sigma

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订货号 0BV8800
品牌型号 Sigma 203800-10MGCN
货期 询货期
最小订货量 1件
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产品介绍 Product Description

General description

Cell-permeable cAMP analog that has greater resistance to phosphodiesterases than cAMP. Preferentially activates protein kinase A (PKA). Directly activates Epac, a Rap1 guanine-nucleotide exchange factor.
Cell-permeable cAMP analog that is more resistant to phosphodiesterases than cAMP. Preferentially activates cAMP-dependent protein kinase (PKA). Induces the guanine-nucleotide-exchange factor activity of GEFI, also known as Epac (exchange protein directly activated by cAMP), and GEFII toward Rap1 both in vivo and in vitro.


Biochem/physiol Actions

Cell permeable: yes
Primary Target
PKA
Product does not compete with ATP.
Reversible: no


Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Avoid pH >8.5.


Other Notes

Kawasaki, H., et al. 1998. Science 282, 2275.
de Rooij, J., et al. 1998. Nature 396, 474.
Boyer, B., and Thiery, J.P. 1993. J. Cell Biol.120, 767.
Hei, Y.-J., et al. 1991. Mol. Pharmacol. 39, 233.


Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany


Disclaimer

Toxicity: Standard Handling (A)


技术参数 Specifications
Quality Level100
assay≥98% (HPLC)
formsolid
manufacturer/tradenameCalbiochem®
storage conditionOK to freeze,desiccated (hygroscopic)
color white
solubilitywater: soluble
shipped inambient
storage temp.−20°C
SMILES string[Na+].[P]1(=O)(O[C@@H]2[C@H](O[C@H]([C@@H]2O)[n]3c4ncnc(c4nc3Br)N)CO1)[O-]
InChI1S/C10H11BrN5O6P.Na/c11-10-15-4-7(12)13-2-14-8(4)16(10)9-5(17)6-3(21-9)1-20-23(18,19)22-6;/h2-3,5-6,9,17H,1H2,(H,18,19)(H2,12,13,14);/q;+1/p-1/t3-,5-,6-,9-;/m1./s1
InChI keyDMRMZQATXPQOTP-GWTDSMLYSA-M
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