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β-Secretase Inhibitor IV，500UG，565794-500UGCN，Sigma

销售价： ¥ 1711.83 / 件

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订货号： 0BW0951

品牌型号： Sigma 565794-500UGCN

货期：询货期

最小订货量： 1件

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商品介绍
规格参数
包装参数

产品介绍 Product Description

General description

A cell-permeable isophthalamide compound containing hydroxyethylamine motif that binds to BACE-1 active site and potently blocks its proteolytic activity (IC₅₀ = 15 nM for BACE-1, human and 29 nM for sAPP_NF in HEK293-APP^NFEV cells). Displays greater selectivity over other aspartyl proteases (IC₅₀ = 0.23 µM, 7.6 µM and >50 µM for BACE-2, cathepsin D, and renin, respectively). The solid form of this compound (Cat. No. 565788 ) is also available.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
β-Secretase
Reversible: yes
Target IC₅₀: 15 nM for BACE-1, human and 29 nM for sAPP_NF in HEK293-APP^NFEV cells

Packaging

Packaged under inert gas

Physical form

A 10 mM (500 µg/86.4 µL) solution of β-Secretase Inhibitor IV (Cat. No. 565788) in DMSO.

Preparation Note

Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C. For short term storage, aliquots are stable for up to 3 months at -20°C.

Other Notes

Stachel, S.J., et al. 2004. J. Med. Chem.47, 6447.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

技术参数 Specifications

Quality Segment	100
assay	≥95% (HPLC)
form	liquid
manufacturer/tradename	Calbiochem^®
storage condition	OK to freeze,avoid repeated freeze/thaw cycles,desiccated (hygroscopic),protect from light
shipped in	dry ice
storage temp.	−70°C
SMILES string	O=C(C1=CC(C(N[C@@H](CC2=CC=CC=C2)[C@H](O)CNC3CC3)=O)=CC(N(S(C)(=O)=O)C)=C1)N[C@H](C)C4=CC=CC=C4
InChI	1S/C31H38N4O5S/c1-21(23-12-8-5-9-13-23)33-30(37)24-17-25(19-27(18-24)35(2)41(3,39)40)31(38)34-28(16-22-10-6-4-7-11-22)29(36)20-32-26-14-15-26/h4-13,17-19,21,26,28-29,32,36H,14-16,20H2,1-3H3,(H,33,37)(H,34,38)/t21-,28+,29-/m1/s1
InChI key	VPNIQGRFZCTBEZ-SPTGULJVSA-N

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