Anti-AOS1 antibody produced in rabbit，100UG，SAB4500028-100UG，Sigma 供应商、价格、厂家、报价、规格参数

产品介绍 Product Description

General description

E1 ubiquitin-activating protein AOS1 also known as SAE1 (SUMOs (small ubiquitin-like modifiers) 1 activating enzyme subunit 1) is encoded by the gene mapped to human chromosome 19. Human ASO1 is expressed throughout nuclei apart from nucleoli.The protein expression is elevated in S phase and decreased in G2 phase of cell cycle.

Immunogen

The antiserum was produced against synthesized peptide derived from human AOS1.

Immunogen Range: 221-270

Biochem/physiol Actions

SAE1 (SUMOs (small ubiquitin-like modifiers) 1 activating enzyme subunit 1)/ AOS1 transcription is induced by Myc via direct binding to canonical E-Boxes sequences present near the SAE1 transcription start site. SAE1 and SAE2/ UBA2 complex plays a crucial role in the tumorigenicity of Myc-dependent cancer cells in vitro and in vivo. SAE1/SAE2 heterodimer complex catalyzes the conjugation of SUMO-1 to a variety of cellular substrates via ATP-dependent reaction, where the first step involves C-terminal adenylation of glycine residues of SUMO-1 and second step involves thioester bond formation between C-terminal glycine of SUMO-1 and a cysteine residue in SAE2.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

技术参数 Specifications

biological source	rabbit
Quality Segment	100
conjugate	unconjugated
antibody form	affinity isolated antibody
antibody product type	primary antibodies
clone	polyclonal
form	buffered aqueous solution
mol wt	antigen 38 kDa
species reactivity	rat, mouse, human
concentration	~1 mg/mL
technique(s)	ELISA: 1:20000,immunofluorescence: 1:100-1:500,western blot: 1:500-1:1000
NCBI accession no.	Q9UBE0
UniProt accession no.	Q9UBE0
shipped in	wet ice
storage temp.	−20°C
target post-translational modification	unmodified
Gene Information	human ... SAE1(10055)

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