- 商品介绍
- 规格参数
- 包装参数
General description
Sob-AM2 is a methyl amide derivative and a central nervous system (CNS)- selective prodrug of Sobetirome. Even in the absence of monocarboxylate transporter 8 (Mct8), Sob-AM2 can penetrate the brain and exhibit thyromimetic effects. It can promote extensive myelin repair in the brain and spinal cord of mouse models with demyelination. Sob-AM2 and other thyromimetics may also stimulate triggering receptor expressed on myeloid cell-2 (TREM2) expression in macrophages and microglia.
Biochem/physiol Actions
CNS-penetrating thyromimetic
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | 2-8°C |
| SMILES string | CC(C1=C(C=CC(CC2=C(C=C(C=C2C)OCC(NC)=O)C)=C1)O)C |
| InChI | 1S/C21H27NO3/c1-13(2)18-10-16(6-7-20(18)23)11-19-14(3)8-17(9-15(19)4)25-12-21(24)22-5/h6-10,13,23H,11-12H2,1-5H3,(H,22,24) |
| InChI key | UWVFEENBJKSTRD-UHFFFAOYSA-N |
| 长度(mm) | |
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| 重量(kg) |
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¥ 12156.68
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¥ 4164.19
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¥ 4173.75
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¥ 8520.40
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