- 商品介绍
- 规格参数
- 包装参数
Biochem/physiol Actions
CAY10566 is a potent and selective stearoyl-CoA desaturase 1 (SCD1) inhibitor (IC50 = 26 nM/hSCD1 and 4.5 nM/mSCD1; IC50 >10 μM/75 receptors, transporters, ion channels). CAY10566 effectively blocks the conversion of saturated long-chain fatty acid-CoAs (LCFA-CoAs) to monounsaturated LCFA-CoAs in HepG2 cells (IC50 = 7.9 nM by C17:1/C17:0 ratio; IC50 = 6.8 nM by C16:1/C16:0 ratio) and exhibits good metabolic stability (by rat & mouse liver microsome assays) and oral availability (rat F = 59.2%; 5 mg/kg p.o.). CAY10566 is typically used in the range from 0.1-10 μM for cell treatment.
Orally available, potent and selective stearoyl-CoA desaturase 1 (SCD1) inhibitor.
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | off-white to orange |
| solubility | DMSO: 2 mg/mL, clear (warmed) |
| storage temp. | 2-8°C |
| SMILES string | Fc1cc(c(cc1)Cl)OC2CCN(CC2)c3nnc(cc3)c4nnc([o]4)C |
| InChI | 1S/C18H17ClFN5O2/c1-11-21-24-18(26-11)15-4-5-17(23-22-15)25-8-6-13(7-9-25)27-16-10-12(20)2-3-14(16)19/h2-5,10,13H,6-9H2,1H3 |
| InChI key | WFOFPVXMPTVOTJ-UHFFFAOYSA-N |
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¥ 12156.68
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¥ 1148.92
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¥ 4164.19
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¥ 2622.09
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¥ 2814.26
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¥ 1866.29
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¥ 3442.25
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