- 商品介绍
- 规格参数
- 包装参数
产品介绍
Product Description
Biochem/physiol Actions
XEN445 is a potent and selective inhibitor of endothelial lipase with an IC50 of 237 nM and high selectivity over hepatic and lipoprotein lipases. In experiments with wild-type mice, XEN445 raised plasma HDL-cholesterol levels by 16% after 3 days and by 30% after 9 days dosing.
XEN445 is a potent and selective inhibitor of endothelial lipase.
技术参数
Specifications
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 10 mg/mL, clear |
| web metadata keyword.default | 1515856-92-4 XEN445,XEN445 (S)-2-(3-(Pyridin-2-ylmethoxy)pyrrolidin-1-yl)-5-(trifluoromethyl)benzoic acid,XEN445 1g vial,XEN445 5g,XEN445 IC50 237 nM,XEN445 Sigma-Aldrich,XEN445 application in cholesterol regulation,XEN445 endothelial lipase inhibitor,XEN445 for HDL-cholesterol studies,XEN445 high purity compound,XEN445 lab-grade inhibitor,XEN445 lipid metabolism research,XEN445 research chemical,XEN445,potent selective inhibitor of endothelial lipase XEN445 |
| storage temp. | 2-8°C |
| SMILES string | FC(F)(F)c1cc(c(cc1)N2C[C@H](CC2)OCc3ncccc3)C(=O)O |
| InChI | 1S/C18H17F3N2O3/c19-18(20,21)12-4-5-16(15(9-12)17(24)25)23-8-6-14(10-23)26-11-13-3-1-2-7-22-13/h1-5,7,9,14H,6,8,10-11H2,(H,24,25)/t14-/m0/s1 |
| InChI key | NBGRERFNOKZQLO-AWEZNQCLSA-N |
| 长度(mm) | |
| 宽度(mm) | |
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| 重量(kg) |
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