- 商品介绍
- 规格参数
- 包装参数
Application
Sorbinil has been used as an aldose reductase inhibitor in diabetic rats as a positive control group.
Sorbinil may be used in cell signaling and neuroscience studies.
Biochem/physiol Actions
Sorbinil decreases the level of sorbitol in red blood cells and increases the velocity of nerve conduction. It maintains the myo-inositol content in the nerve and prevents the reduction of sodium-potassium ATPase activity. This action is beneficial in providing symptomatic relief in patients with diabetic neuropathy.
Sorbinil is an inhibitor of Aldose Reductase (AR). AR family members AKR1B1 and AKR1B10 have additionally been shown to play roles in inflammation and cancer.
Sorbinil is an inhibitor of Aldose Reductase.
Features and Benefits
This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| optical activity | [α]/D +50 to +60°, c = 1 in methanol |
| color | white to off-white |
| solubility | DMSO: ≥20 mg/mL |
| storage temp. | 2-8°C |
| SMILES string | Fc1ccc2OCC[C@]3(NC(=O)NC3=O)c2c1 |
| InChI | 1S/C11H9FN2O3/c12-6-1-2-8-7(5-6)11(3-4-17-8)9(15)13-10(16)14-11/h1-2,5H,3-4H2,(H2,13,14,15,16)/t11-/m0/s1 |
| InChI key | LXANPKRCLVQAOG-NSHDSACASA-N |
| 长度(mm) | |
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| 重量(kg) |
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NALGENE 180透明塑料管，透明，柔软，多用，经济，内径 x 外径x壁厚，1/8 x 1/4 x 1/16，英寸，每箱数量50，50/箱，8000-0020，Thermofisher，赛默飞世尔
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