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- 规格参数
- 包装参数
General description
Regulator of G-protein signaling 4 (RGS4) is a GTPase activating protein belonging to the RGS family. This is a group of proteins known to act as GTPase activating proteins (GAPs), in order to regulate G protein signaling. RGS4 is highly expressed throughout the brain with highest expression observed in the prefrontal cortex, and some expression found in peripheral tissues such as the heart. RGS4 acts as a signal transduction inhibitor by inactivating G protein alpha subunits through the increase of their GTPase activity. Also, RGS4 serves to enhance Gi/o and Gq/11 protein GTPase activity and to expedite the conclusion of GPCR signaling. Various studies indicate a potential role for RGS4 in the regulation of various neurotransmitter systems, including those with putative involvement in schizophrenia. Mutations in the RGS4 gene lead to a lower presence of RGS4, linked to both Schizophrenia and Alzheimer’s symptoms.
~ 23 kDa MW observed. A non-specific band appears at ~ 12 kDa
Immunogen
Recombinant protein corresponding to rat RGS4.
Application
Detect RGS4 using this Anti-RGS4 Antibody validated for use in WB.
Research Category
Cell Structure
Signaling
Research Sub Category
Cytoskeletal Signaling
G-proteins
Western Blot Analysis: 1:1,000 dilution from a representative lot detected RGS4 on 10 µg of recombinant RGS4.
Physical form
Rabbit polyclonal serum containing 0.05% sodium azide.
Unpurified
Preparation Note
Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Analysis Note
Control
PC12 cell lysate
Evaluated by Western Blot in PC12 cell lysate.
Western Blot Analysis: 1:1000 dilution of the antibody detected RGS4 in 10 µg of PC12 cell lysate.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | serum |
| antibody product type | primary antibodies |
| clone | polyclonal |
| species reactivity | rat |
| technique(s) | western blot: suitable |
| isotype | IgG |
| NCBI accession no. | NP_058910 |
| UniProt accession no. | P49799 |
| shipped in | wet ice |
| target post-translational modification | unmodified |
| Gene Information | human ... RGS4(5999) |
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¥ 12156.68
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¥ 1683.78
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¥ 1573.49
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¥ 3152.47
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¥ 4968.78
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¥ 2883.61
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瓶顶过滤器-500ml容量,MF75TM系列，聚苯乙烯外壳，75mmPES滤膜，孔径0.45um,适合瓶颈尺寸33mm，12/箱，295-3345，Nalgene，Thermofisher，赛默飞世尔¥ 1938.54
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