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Anti-Abl (c-, v-, Bcr-) Antibody, clone 24-21，100UG，MABT203，Sigma

销售价： ¥ 4665.43 / 件

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订货号： 0BV3686

品牌型号： Sigma MABT203

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最小订货量： 1件

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产品介绍 Product Description

General description

c-Abl, v-Abl, and Bcr-abl are ubiquitously expressed non-receptor tyrosine kinases that are involved in a plethora of cellular processes. c-Abl is involved in cytoskeleton remodeling and facilitates cell adhesion and cell motility. c-Abl achieves cytoskeleton remodeling by phosphorylating and activating a wide variety of cytoskeleton-associated proteins such as WASF3, ANXA1, DBN1, DBNL, CTTN, RAPH1, ENAH, MAPT, and PXN. Abl-1 also phosphorylates a number of receptor tyrosine kinases and is involved in regulating levels of EGFR by endocytosis. c-Abl may also play a role in DNA damage response via the ATM pathway, among other cellular processes. Whereas v-Abl is known to be involved in pre-B cell transformation in mice, Bcr-Abl is reported to promote cellular growth in leukemia cells and maintain CML phenotype. Many v-Abl- and Bcr-abl-mediated signaling events have been described; however the complexity and function of these pathways require further elucidation.
~125 kDa and ~190 kDa observed. Uniprot describes a molecular weight of c-Abl at ~122 kDa Uniprot describes that this protein is subject to post-translational modification. This antibody detected c-Abl (~125 kDa) and Bcr-Abl (~190 kDa) in K562 cell lysate. An uncharacterized band at ~27 kDa may be observed in some cell lysates.

Immunogen

Recombinant protein corresponding to the carboxyl region of human v-Abl fused with TrpE.

Application

Anti-Abl (c-, v-, Bcr-) Antibody, clone 24-21 detects level of Abl (c-, v-, Bcr-), clone 24-21 & has been published & validated for use in Western Blotting, ICC.
Immunocytochemistry Analysis: A representative lot from an independent laboratory detected Abl (c-, v-, Bcr-) in COS-7 and 7C411 cells (Goga, A., et al. (1993). Mol Cell Biol. 13(8):4967-49775.).

Biochem/physiol Actions

This antibody recognizes the c-terminus of c-Abl, v-Abl, and Bcr-Abl.

Physical form

Format: Purified

Analysis Note

Evaluated by Western Blot in K562 cell lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected Abl (c-, v-, Bcr-) in 10 µg of K562 cell lysate.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

技术参数 Specifications

biological source	mouse
Quality Level	100
conjugate	unconjugated
antibody form	purified antibody
antibody product type	primary antibodies
clone	24-21, monoclonal
species reactivity	human
technique(s)	immunocytochemistry: suitable,western blot: suitable
isotype	IgG1κ
NCBI accession no.	NP_005148
UniProt accession no.	P00519
shipped in	wet ice
target post-translational modification	unmodified
Gene Information	human ... ABI1(10006)

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