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General description
FABP1, also known as Fatty acid-binding protein, Liver Fatty acid-binding protein, Fatty acid-binding protein 1, Liver-type fatty acid-binding protein, L-FABP, Squalene- and sterol-carrier protein, SCP, Z-protein, or p14, and encoded by the gene FABP1/FABPL, is an important fatty acid binding and transport protein. FABP1 is produced in the liver and is part of a family of lipid carrier proteins. FABP1 facilitate the transfer of fatty acids between extra and intracellular membranes. FABP1 level in the blood is used as a biomarker for obesity and type II diabetes. Additionally, recent research indicates that FABP1 can modulate stellate cell activation and this may lead to diet-induced nonalcoholic fatty liver disease, thus FABP1 is a key focus of metabolic research.
~14 kDa observed
Immunogen
Epitope: Near N-terminus
KLH-conjugated linear peptide corresponding to human FABP1 near the N-terminus.
Application
Immunohistochemistry Analysis: A 1:2,000 dilution from a representative lot detected FABP1 in rat liver tissue.
Research Category
Apoptosis & Cancer
Research Sub Category
Apoptosis - Additional
This Anti-FABP1 Antibody is validated for use in Western Blotting and Immunohistochemistry for the detection of FABP1.
Biochem/physiol Actions
Other homologies: Mouse (94% sequence homology).
Physical form
Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Evaluated by Western Blotting in HepG2 cell lysate.
Western Blotting Analysis: 2.0 µg/mL of this antibody detected FABP1 in 10 µg of HepG2 cell lysate.
Other Notes
Concentration: Please refer to lot specific datasheet.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| purified by | affinity chromatography |
| species reactivity | rat, human |
| species reactivity (predicted by homology) | primate (based on 100% sequence homology) |
| technique(s) | immunohistochemistry: suitable,western blot: suitable |
| NCBI accession no. | NP_001434 |
| UniProt accession no. | P07148 |
| shipped in | wet ice |
| target post-translational modification | unmodified |
| Gene Information | human ... FABP1(2168) |
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