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Biochem/physiol Actions
AS3334034 is an orally available, potent and selective RIP2 (Receptor-interacting protein kinase 2) inhibitor that exhibits renoprotective effects in uninephrectomized adriamycin-induced CKD (chronic kidney disease) rats. It appears that AS3334034 suppresses the progression of chronic renal failure via an anti-inflammatory effect.
Orally available, potent and selective RIP2 inhibitor that exhibits renoprotective effects
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear (warmed) |
| storage temp. | 2-8°C |
| SMILES string | CC1=CNN=C1NC2=CC=NC3=CC(OC)=C(S(=O)(C(C)(C)C)=O)C=C32 |
| InChI | 1S/C18H22N4O3S/c1-11-10-20-22-17(11)21-13-6-7-19-14-9-15(25-5)16(8-12(13)14)26(23,24)18(2,3)4/h6-10H,1-5H3,(H2,19,20,21,22) |
| InChI key | WCPMUQAUSFXFJE-UHFFFAOYSA-N |
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¥ 2013.69
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¥ 6894.69
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¥ 9737.84
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¥ 1476.00
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¥ 4020.77
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¥ 787.34
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¥ 1476.40
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¥ 3031.24
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¥ 2452.91
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¥ 954.17
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¥ 165230.53
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¥ 8072.66
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