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General description
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated.
Immunogen
A synthetic dimethylated peptide around K44 of mouse DNMT3A (NP_031898.1).
Physical form
Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
| biological source | rabbit |
| Quality Segment | 100 |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | liquid |
| concentration | 1.16 mg/mL |
| technique(s) | immunohistochemistry: 1:50-1:200 |
| UniProt accession no. | O88508 |
| shipped in | wet ice |
| storage temp. | −20°C |
| target post-translational modification | dimethylation (Lys44) |
| Gene Information | mouse ... TMEM173(13435) |
| 长度(mm) | |
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