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General description
α1-syntrophin (SNTA1) is a dystrophin-associated protein, that has four domains- a postsynaptic density protein-95/disc large/zona occludens-1 (PDZ) domain, two pleckstrin homology (PH1 and PH2) domains and a syntrophin unique (SU) domain. It is located on human chromosome 20q11.2. It is usually present in the peripheral cytoplasmic membrane.
Anti-α1-Syntrophin (RA-16) is developed in rabbit using a synthetic peptide corresponding to a sequence of mouse α1-syntrophin The syntrophins are a family of intracellular peripheral membrane proteins (58-60 kDa), comprising at least three isoforms α1, β1, and β2-syntrophins. Syntrophins in mammalian skeletal muscle have been shown to be part of a complex of proteins associated with dystrophin, the product of Duchenne/Becker muscular dystrophy gene. The C-terminal 57 amino acids region of syntrophins is highly conserved among the three isoforms, and may contain the binding site for dystrophin.
Immunogen
synthetic peptide corresponding to a sequence of mouse α1-syntrophin (amino acids 191-206 with N-terminally added lysine) conjugated to KLH.
Application
Anti-α1-Syntrophin (RA-16) antibody produced in rabbit has been used in immunohistochemistry and immunoblotting.
Biochem/physiol Actions
α1-Syntrophin recruit signaling proteins(2) to the membrane via association with the dystrophin complex.
α1-syntrophin (SNTA1) mutations results in LQTS (cardiac channelopathies like long QT syndrome). It modulates the development of adipocyte lipid droplet. It also participates in the survival signaling pathway in myoblasts. α1-syntrophin controls voltage-gated Na+ channels. It acts as a substrate for stress-activated protein kinase-3 (SAPK-3).
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Segment | 200 |
| conjugate | unconjugated |
| antibody form | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | buffered aqueous solution |
| mol wt | antigen 60 kDa |
| species reactivity | rat |
| technique(s) | immunohistochemistry (frozen sections): suitable using 0.5% paraformaldehyde fixed/0.5% Triton X-100 treated rat skeletal muscle,microarray: suitable,western blot: 1:2,000 using rat skeletal muscle homogenate extract (membrane fraction) |
| shipped in | dry ice |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| Gene Information | mouse ... Snta1(20648) rat ... Snta1(362242) |
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