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- 规格参数
- 包装参数
Application
SKF-83959 was used in dopamine signaling studies on eye blinking in monkeys and on phosphorylation of CaMKIIα in mice.
Biochem/physiol Actions
D1 dopamine receptor agonist. Displays antagonist activity in vitro and agonist activity in vivo.
SKF-83959 is an atypical agonist of D1 dopamine receptor and an allosteric modulator of σ-1 receptor on in brain and liver tissues. It has neuroprotective and anti-parkinsonian effects through selective activation of phosphoinositol-linked D1 receptor and promotes migration of cultures astrocytes by ERK1/2 activation. In in vitro studies SKF-83959 exhibits antagonist activity against dopamine D1 receptors coupled to adenylyl cyclase.
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | solid |
| color | white |
| solubility | DMSO: >20 mg/mL,H2O: insoluble |
| SMILES string | Br[H].CN1CCc2c(Cl)c(O)c(O)cc2C(C1)c3cccc(C)c3 |
| InChI | 1S/C18H20ClNO2.BrH/c1-11-4-3-5-12(8-11)15-10-20(2)7-6-13-14(15)9-16(21)18(22)17(13)19;/h3-5,8-9,15,21-22H,6-7,10H2,1-2H3;1H |
| InChI key | FHYWNBUFNGHNCP-UHFFFAOYSA-N |
| Gene Information | human ... DRD1(1812) |
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