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Biochem/physiol Actions
CuATSM analog with >10-fold enhanced ferropotosis inhibitory potency.
CuATSP is a CuATSM analog with >10-fold enhanced ferropotosis inhibitory potency (CuATSP/CuATSM IC50 against 150 nM RSL3-induced ferroptosis = 8.5/160 nM using Pfa1 mouse embryonic fibroblasts,16/170 nM using HT-22 mouse hippocampal cells). CuATSP and CuATSM exert their radical-trapping antioxidant (RTA) and (phospho)lipid peroxidation inhibitory potency via an initial reversible addition of a peroxyl radical to the bis(thiosemicarbazone) ligand, followed by a subsequent H-atom transfer (HAT) that drives the reaction forward.
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | , Faint brown to dark red |
| solubility | DMSO: 2 mg/mL, clear (Warmed) |
| storage temp. | 2-8°C |
| SMILES string | CC1=[N]2[Cu]3(SC(NC4=CC=CC=C4)=N2)SC(NC5=CC=CC=C5)=N[N]3=C1C |
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¥ 95.27
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