Anti-ERGIC-53 antibody, Mouse monoclonal，200UL，SAB4200585-200UL，Sigma 供应商、价格、厂家、报价、规格参数

产品介绍 Product Description

General description

Endoplasmic reticulum-Golgi intermediate compartment 53kDa protein (ERGIC-53), a nonglycosylated, hexameric type I integral membrane protein is also known as LMAN1 (lectin, mannose-binding 1). This gene is located on human chromosome 18q21.32.

Immunogen

synthetic peptide corresponding to an internal sequence of human ERGIC-53, conjugated to KLH. The corresponding sequence is identical in mouse, rat, bovine and monkey.

Biochem/physiol Actions

Endoplasmic reticulum-Golgi intermediate compartment protein 53kDa protein (ERGIC-53) plays an important role in the proliferation of arenavirus, coronavirus and filovirus. This intracellular cargo receptor enables the anterograde passage of very few glycoprotein ligands in the early exocytic pathway. Mutations in ERGIC-53 (LMAN1) gene results in the deficiency of factor V and factor VIII.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

技术参数 Specifications

biological source	mouse
Quality Level	200
conjugate	unconjugated
antibody form	purified from hybridoma cell culture
antibody product type	primary antibodies
clone	ERGIC-3, monoclonal
form	buffered aqueous solution
mol wt	antigen ~58 kDa
species reactivity	mouse, human, rat
concentration	~1 mg/mL
technique(s)	immunoblotting: 1-2 μg/mL using whole extracts of human HeLa cells.
isotype	IgG1
UniProt accession no.	P49257
shipped in	dry ice
storage temp.	−20°C
target post-translational modification	unmodified
Gene Information	human ... LMAN1(3998) mouse ... Lman1(70361) rat ... Lman1(116666)

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