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Biochem/physiol Actions
Talnetant (SB-223,412) is a highly selective antagonist of neurokinin 3 receptor with a Ki (NK3) = 1 nM >10000 (NK1) >140 (NK2). Neurokinins (tachykinins) are members of a family of at least three neuropeptides, substance P, neurokinin A, and neurokinin B (NKB), with each mediating their biological effects through binding to a preferred G-protein-coupled receptor termed NK1, NK2, or NK3, respectively. All three NK receptors are expressed in regions of the central nervous system that are related to emotion and cognition (i.e., amygdala and hippocampus) and have been linked to various degrees in psychiatric disorders. Neurokinin receptors, including NK3 receptors, are also expressed in the motor and sensory systems of the digestive tract. Talnetant was in clinical trials for both irritable bowel syndrome and schizophrenia.
Talnetant is a highly selective antagonist of neurokinin 3 receptor.
Features and Benefits
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| optical activity | [α]/D -25 to -31°, c = 0.5 in methanol |
| color | white to beige |
| solubility | DMSO: 25 mg/mL, clear |
| storage temp. | 2-8°C |
| SMILES string | OC(C(C(N[C@H](C1=CC=CC=C1)CC)=O)=C(C=CC=C2)C2=N3)=C3C4=CC=CC=C4 |
| InChI | 1S/C25H22N2O2/c1-2-20(17-11-5-3-6-12-17)27-25(29)22-19-15-9-10-16-21(19)26-23(24(22)28)18-13-7-4-8-14-18/h3-16,20,28H,2H2,1H3,(H,27,29)/t20-/m0/s1 |
| InChI key | BIAVGWDGIJKWRM-FQEVSTJZSA-N |
| Gene Information | human ... TACR3(6870) |
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¥ 4164.19
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¥ 2814.26
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¥ 3290.05
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¥ 2883.61
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¥ 4390.38
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瓶顶过滤器-500ml容量,MF75TM系列，聚苯乙烯外壳，75mmSFCA滤膜，孔径0.2um,适合瓶颈尺寸45mm，12/箱，291-4520，Nalgene，Thermofisher，赛默飞世尔¥ 2856.42
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¥ 787.34
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¥ 1586.69
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