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Biochem/physiol Actions
Nitecapone is a short-acting inhibitor of catechol-O-methyltransferase (COMT).
Nitecapone is a short-acting inhibitor of catechol-O-methyltransferase (COMT). Nitecapone displays in vivo activity in peripheral tissues, but does not pentrate the blood brain barrier. The compound increases mechanical and thermal nociception, and reduces neuropathic pain in diabetic rats and in a spinal nerve ligation model.
Features and Benefits
This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 15 mg/mL, clear |
| storage temp. | −20°C |
| SMILES string | [N+](=O)([O-])c1c(c(cc(c1)C=C(C(=O)C)C(=O)C)O)O |
| InChI | 1S/C12H11NO6/c1-6(14)9(7(2)15)3-8-4-10(13(18)19)12(17)11(16)5-8/h3-5,16-17H,1-2H3 |
| InChI key | UPMRZALMHVUCIN-UHFFFAOYSA-N |
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¥ 4164.19
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¥ 1653.62
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