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Biochem/physiol Actions
Orally available, potent, and selective agonist of Trace amine-associated receptor 1 (TAAR1); dual activator of Gs and Gq in mTAAR1/hTAAR1.
ZH8651 is an orally available, potent, and selective agonist of Trace amine-associated receptor 1 (TAAR1). ZH8651 is dual activator of Gs and Gq in mTAAR1/hTAAR1 (EC50 = 9,85 nM (Gs), 66.5 nM Gq). ZH8651 alleviates MK-801-induced schizophrenia-like phenotypes without inducing catalepsy in mice.
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| storage condition | desiccated |
| color | white to beige |
| solubility | H2O: 2 mg/mL, clear |
| storage temp. | 2-8°C |
| SMILES string | BrC1=CC=C(C=C1)CCN.Cl |
| InChI | 1S/C8H10BrN.ClH/c9-8-3-1-7(2-4-8)5-6-10;/h1-4H,5-6,10H2;1H |
| InChI key | ZHAWIPAHUYMLDV-UHFFFAOYSA-N |
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