VHL Binder 30，5MG，SML4012-5MG，Sigma

Biochem/physiol Actions

Binds to the VHL protein with high-affinity and efficiently disrupts VHL-HIF-α interaction.



VHL Binder 30 (VHL Binder, Compound 30) is a highly potent, efficacious von Hippel−Lindau (VHL) E3 ubiquitin ligase binder with greater cell permeability, higher binding affinity (Kd = 37 & 25 nM by fluorescence polarization and surface plasmon resonance, respectively) and superior ability to induce Hypoxia-inducible factor-1α (HIF-1α) transcriptional activity (% of HIF-1α stabilization levels at 50 µM for 2 hr = 182 & 224 in HeLa & HEK293 cells; HIF-1α-OH stabilization at 50 µM for 2 hr = 263, 208 in HeLa & HEK293 cells, respectively; VH298 as the reference ligand VH298).