FDW028，25MG，SML4030-25MG，Sigma

Biochem/physiol Actions

Potent FUT8 inhibitor, demonstrates potent efficacy against metastatic colorectal cancer.

FDW028, a potent and selective FUT8 (fucosyltransferase 8) inhibitor, enhances survival in colorectal cancer metastasis in mice (20 mg/kg, i.v. once the other day) by targeting FUT8 (Kd = 5.486 μM), leading to defucosylation and lysosomal degradation of B7-H3 through the chaperone mediated autophagy pathway in CRC cells. This destabilization is facilitated by increased B7-H3 interactions with HSC70/LAMP2A. FDW-028 shows promising anti-tumor abilities in inhibition of clone formation and cell proliferation in SW480 and HCT-8 cells with IC50 values of 5.95 µM and 23.78 µM, respectively.