HBX 41,108，5MG，SML3415-5MG，Sigma

Biochem/physiol Actions

Catalytic site-targeting, uncompetitive, potent and reversible ubiquitin-specific protease USP7 inhibitor.
HBX 41,108 is a catalytic site-targeting, uncompetitive, potent and reversible ubiquitin-specific protease (USP) inhibitor (USP7/HAUSP IC50 = 420 nM) with little potency toward aspartic, serine or other non-USP cysteine proteases. HBX 41,108 exhibits antiproliferation potency in cancer cultures (HCT116 GI50 = 1 μM post 24 h treatment) by preventing USP7-mediated p53 deubiquitination and thereby promoting p53 target genes expression and inducing p53-dependent apoptosis.