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General description
Anti-K+/Cl- Cotransporter (KCC2) specifically recognizes K+/Cl- cotransporter (KCC2). The cation-chloride cotransporters (CCCs) are glycoproteins involved in transport of ions, includingchloride, across the ce
Transporters and exchangers play a critical role in the generation and dissipation of action potentials in nerve cells and in the maintenance of normal cell volume. They are also involved in a variety of mechanisms pertaining to the control of neuronal growth, maturation, synaptic plasticity and neuroendocrine functions
The cation-chloride cotransporters (CCCs) are glycoproteins involved in transport of ions, including chloride, across the cell membrane without an accompanying net charge movement; thus this type of transport is driven without the direct hydrolysis of ATP. The energy for the transport is derived from the cation gradient generated by the Na+/K+/ATPase. The CCCs also play a critical role in influencing GABA- and glycine-mediated signaling. Other transporters that participate in chloride homeostasis include Na+-dependent and Na+-independent anion exchangers, which exchange chloride for HCO3- ions
Three cotransporters belonging to this family include sodiumchloride( Na+/Cl-/ ) cotransporters (NCCs), sodiumpotassium-chloride (Na+/K+/2Cl-) cotransporters (NKCCs) and potassium-chloride (K+/Cl-) cotransporters (KCCs). K+/Cl- cotransporter (KCC2) is the major neuronal chloride transporter. It has been proposed to play a role in the modulation of neuronal responses to γ-aminobutyric acid (GABA). GABA-mediated fasthyperpolarizing inhibition depends on extrusion of chloride by KCC2 In conditions of neuronal damage, where neuronal excitability is increased, and in spinal cord in models of neuropathic pain, the expression of the KCC2 transporter is decreased
Immunogen
N-terminal His-tag fusion protein corresponding to residues 932-1043 of rat K+/Cl- Cotransporter (KCC2).
Application
Anti-K+/Cl- Cotransporter (KCC2) specifically recognizes K+/Cl- cotransporter in rat brain membrane preparations by immunoblotting and Madin Darby Canine Kidney (MDCK) cells by immunocytochemistry.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunocytochemistry (1 paper)
Biochem/physiol Actions
Wide range of species cross-reactivity expected due to sequence homology.
Anti-K+/Cl- Cotransporter (KCC2) specifically recognizes K+/Cl- cotransporter. Wide range of species cross-reactivity expected due to sequence homology.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Level | 200 |
| conjugate | unconjugated |
| antibody form | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | buffered aqueous solution |
| species reactivity | canine, rat |
| technique(s) | western blot: 0.5-2.0 μg/mL using rat brain membrane preparation |
| web metadata keyword.default | 1,2-dibromo-3,4,5,6-tetrachloro-benzene CAS number,1,2-dibromo-3,4,5,6-tetrachloro-benzene analytical grade,1,2-dibromo-3,4,5,6-tetrachloro-benzene applications in research,1,2-dibromo-3,4,5,6-tetrachloro-benzene chemical structure,1,2-dibromo-3,4,5,6-tetrachloro-benzene for organic synthesis,1,2-dibromo-3,4,5,6-tetrachloro-benzene in environmental testing,1,2-dibromo-3,4,5,6-tetrachloro-benzene reagent for chromatography,1,2-dibromo-3,4,5,6-tetrachloro-benzene synthesis procedures,1,2-dibromo-3,4,5,6-tetrachloro-benzene,Sigma-Aldrich 1,2-dibromo-3,4,5,6-tetrachloro-benzene,high purity 1,2-dibromo-3,4,5,6-tetrachloro-benzene,laboratory grade 1,2-dibromo-3,4,5,6-tetrachloro-benzene |
| UniProt accession no. | Q63633 |
| shipped in | dry ice |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| Gene Information | rat ... Slc12a5(171373) |
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¥ 1259.40
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¥ 4173.75
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¥ 238.17
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¥ 3290.05
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¥ 1653.62
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¥ 8982.64
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¥ 3319.60
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¥ 8137.12
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¥ 2277.64
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