规格
|
Accession Number:
|
CDK11: NP_055891.1, Cyclin C: NP_005181.2 |
Protein Form:
|
Recombinant, Active, Catalytic |
Shipping Condition:
|
Dry Ice |
Molecular Weight:
|
84.9/38.0 kDa |
Validated Application:
|
Kinase Assay |
Expression System:
|
Insect |
KinaseFamily:
|
CDKs and CHKs |
Protein Length:
|
CDK11: 1 - 502, Cyclin C: 1 - 283 |
Protein Tag:
|
GST Tag, His Tag |
储存
|
Storage Buffer: 50 mM HEPES pH 7.5, 100 mM NaCl, 5 mM DTT, 20% glycerol |
This CDK11/cyclin C recombinant human protein (CDK11: 1–502, cyclin C: 1–283) was expressed in insect cells. CDK11/cyclin C serine/threonine kinase is dimeric protein complex. CDK11 is one of the components of the Mediator co-activator complex. The Mediator complex is a multi-protein complex required for transcriptional activation by DNA binding transcription factors of genes transcribed by RNA polymerase II. Cyclin C is a member of the cyclin family of proteins. The encoded protein interacts with cyclin-dependent kinase 8 and induces the phophorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II. CDK11/cyclin C recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.
• Validated for use with the LanthaScreen™ Eu Kinase Binding assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service