- 商品介绍
- 规格参数
- 包装参数
General description
The small ubiquitin-related modifier SUMO-1 belongs to the growing family of ubiquitin-related proteins involved in post translational protein modification1. It is present in all eukaryotic kingdoms and is highly conserved from yeast to humans. SUMO-1 does not appear to target proteins for degradation but seems to be involved in the modulation of protein-protein interactions. An increasing number of SUMO-1 substrates are being described but three major substrates for SUMO-1 modification are RanGAP1 and PML proteins.
Immunogen
Synthetic peptide corresponding to amino acid residues 11-101 of human SUMO-1.
Application
Anti-SUMO-1 Antibody detects level of SUMO-1 & has been published & validated for use in WB.
Biochem/physiol Actions
Recognizes SUMO-1. This antibody shows no cross-reactivity with ubiquitin, multi-ubiquitin chains, SUMO2/3, UCRP, Nedd8, and FAT10.
Physical form
100 µL of purified by salt precipitation in PBS containing 0.01% sodium azide. Dilute to working strength with 50mM Tris-HCl buffer (pH 7.6) containing 1.5% sodium chloride and 1% normal goat serum (if a goat anti-rabbit IgG linker antibody is to be used).
Format: Purified
Other Notes
Replaces: 04-453
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
| biological source | rabbit |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | purified antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| species reactivity (predicted by homology) | all |
| manufacturer/tradename | Upstate® |
| technique(s) | western blot: suitable |
| isotype | IgG |
| NCBI accession no. | NM_001005781.1,NM_001005782.1,NM_003352.4 |
| UniProt accession no. | P63165 |
| shipped in | dry ice |
| target post-translational modification | unmodified |
| Gene Information | human ... SENP2(59343), SUMO1(7341) |
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