- 商品介绍
- 规格参数
- 包装参数
General description
A cell-permeable, reversible dipeptide aldehyde that reduces Aβ production by blocking γ-secretase activity in vitro (Aβ40 IC50 = 7.9 µM; Aβ42 IC50 = 7.6 µM) and in cultured CHO 2b-7 cells that stably overexpress APP695 (Aβ40 IC50 = 11.5 µM; Aβ42 IC50 = 8.3 µM). Also blocks the generation of CTFγ (γ-secretase-generated carboxyl-terminal fragment). Does not affect the formation of amyloid-β-precursor protein (APP).
Biochem/physiol Actions
Cell permeable: yes
Primary Target
Aβ40 in vitro
Product does not compete with ATP.
Reversible: yes
Target IC50: 7.9 µM for Aβ40; 7.6 µM for Aβ42 in vitro
Packaging
Packaged under inert gas
Other Notes
Weijzen, S., et al. 2002. Nat. Med.8, 979.
McLendon, C., et al. 2000. FASEB J.14, 2383.
Z-Ile-Leu-CHO
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
| Quality Segment | 100 |
| assay | ≥95% (HPLC) |
| form | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition | OK to freeze,protect from light |
| color | white |
| solubility | DMSO: 5 mg/mL |
| shipped in | ambient |
| storage temp. | −20°C |
| 长度(mm) | |
| 宽度(mm) | |
| 高度(mm) | |
| 重量(kg) |
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