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General description
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1protein (P-Rex1) is a guanine nucleotide exchange factor, which is predominantly expressed in the brain and leucocytes. It exchanges GDP for GTP in Rac 1, resulting in activation of Rac and its downstream signaling molecules that mediate such cellular processes as axon migration and differentiation.
~186 kDa observed
Immunogen
Linear peptide corresponding to human P-Rex 1.
Application
Research Category
Apoptosis & Cancer
Research Sub Category
Apoptosis - Additional
This Anti-P-Rex1, clone 6F12 is validated for use in IP, WB, IH for the detection of P-Rex1.
Western Blot Analysis: A representative lot was used by an independent laboratory to detect P-Rex 1 in PC3 cell lysate (Donald, S.,et al., 2010.), bone-marrow-derived neutrophils from mice (Qin, J., et al., 2009.), and mouse brain sections. (Welch, H, et al., 2005.)
Physical form
Format: Purified
Protein G Purified
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Control
THP-1 cell lysate
Evaluated by Western Blot in THP-1 cell lysate.
Western Blot Analysis: A 1:1,000 dilution of this antibody detected P-Rex 1 in 10 µg of THP-1 cell lysate.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | mouse |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone | 6F12, monoclonal |
| species reactivity | human |
| technique(s) | western blot: suitable |
| isotype | IgG1κ |
| NCBI accession no. | NP_065871 |
| UniProt accession no. | Q8TCU6 |
| shipped in | wet ice |
| target post-translational modification | unmodified |
| Gene Information | human ... PREX1(57580) |
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¥ 807.83
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¥ 3254.04
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¥ 1137.02
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¥ 298.24
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¥ 3254.85
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¥ 1608.31
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¥ 634.68
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¥ 540.59
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