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- 规格参数
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General description
A blood brain barrier permeable pyrimidinyl-aminothiazole compound that specifically interacts with TACC3 (transforming acidic coiledcoil-containing protein 3) and promotes nuclear localization of ARNT2 (aryl-hydrocarbon receptor nuclear translocator 2). Shown to significantly induce neuronal differentiation of cultured rat hippocampal NPCs (neural progenitor cells; EC50 ~ 1 µM) and in adult rats (6 mg/kg, s.c.) and suppress proliferation.
Packaging
Packaged under inert gas
Other Notes
Wurdak, H., et al. 2010. Proc. Natl. Acad. Sci. USA107, 16542
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
| Quality Segment | 100 |
| assay | ≥95% (HPLC) |
| form | resin (Sticky) |
| manufacturer/tradename | Calbiochem® |
| storage condition | OK to freeze,protect from light |
| color | yellow |
| solubility | DMSO: 100 mg/mL |
| shipped in | wet ice |
| storage temp. | 2-8°C |
| SMILES string | [s]1c(nc(c1)CNc3nc(ccn3)NCC(C)C)c2ccccc2 |
| InChI | 1S/C18H21N5S/c1-13(2)10-20-16-8-9-19-18(23-16)21-11-15-12-24-17(22-15)14-6-4-3-5-7-14/h3-9,12-13H,10-11H2,1-2H3,(H2,19,20,21,23) |
| InChI key | DGRJOOOHPBSAHD-UHFFFAOYSA-N |
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