- 商品介绍
- 规格参数
- 包装参数
General description
Parkin is an E3-ubiquitin ligase belonging to the RBR (RING – In Between RING – RING) family. Mutations in Parkin that result in a loss-of-function are the most frequent cause of familial Parkinson’s disease and are responsible for a large percentage of autosomal recessive juvenile parkinsonism (AR-JP). In addition to its auto-ubiquitination, Parkin can also ubiquitinate various substrates, including the CDK2-interacting protein cyclin E1, the a-synuclein-interacting protein synphilin-1, the synaptic vesicle-associated CDC-rel1 and the p38 subunit of aminoacyl-tRNA synthetase/JTV-1. Ubiquitination of substrates occurs in conjunction with the E2 enzymes UbcH7, UbcH8 or UbcH13/Uev1.
Application
Ubiquitination Cascade Comoponent: E3
Physical form
Purified using immobilized metal affinity chromatography.
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | human |
| Quality Segment | 100,300 |
| recombinant | expressed in Sf21 cells |
| manufacturer/tradename | Upstate® |
| technique(s) | activity assay: suitable |
| NCBI accession no. | NM_004562 |
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¥ 1302.89
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¥ 2019.57
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¥ 1956.41
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¥ 6894.69
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¥ 8135.09
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¥ 5725.45
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¥ 2573.97
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¥ 2888.88
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¥ 39793.68
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