SMC®胰高血糖素高灵敏度试剂盒，96WELLS，03-0153-00，密理博

General description

Glucagon is a peptide hormone secreted by pancreatic alphacells that plays a vital role in maintaining glucose homeostasis. It acts as acounter-regulatory hormone to insulin by stimulating glycogenolysis andgluconeogenesis in the liver, thereby increasing blood glucose levels duringfasting or hypoglycemia. In addition to its role in glucose metabolism,glucagon also influences lipid metabolism and energy balance, making it a keybiomarker in metabolic and endocrine research.

Altered glucagon levels are associated with metabolicdisorders such as type 2 diabetes, obesity, and insulin resistance. Accuratemeasurement of glucagon is essential for understanding pancreatic function,evaluating therapeutic interventions, and studying the hormonal regulation ofenergy metabolism.

Application

Metabolism

Features and Benefits

• Ultra-Sensitive Detection — Quantifies glucagon down to 0.20 pg/mL
• Wide Dynamic Range — Covers 0.20–200 pg/mL
• SMC^® Technology — Enables single molecule resolution for precise quantification
• Species Compatibility — Validated for human, mouse, and rat plasma
• Detect Glucagon at Femto-Level Sensitivity — Ideal for metabolic and endocrine research
• Reliable Across Species — Supports translational studies from animal models to human samples
• Accurate Results with Minimal Interference — Trusted data in complex biological fluids

Packaging

96 well assay

Analysis Note

• Sensitivity: LLOQ 781 fg/mL* (SMCxPRO^® Instrument)
• Standard Curve Range: 200-200,000 fg/mL
• Intra-assay CV: <15%
• Inter-assay CV: <20%
• Linearity: Plasma: 86%
• Recovery: Plasma: 86%
• *Indicative LLOQ created from average of 14 independent in house runs,where >80% met same value defined with CV & Recovery +/- 20%. Refer toCoA for lot specific performance.

Other Notes

Glucagon (human) was found to be 100% detectable. Oxyntomodulin (human) was found to be <0.5% detectable. GLP-1 (human) was not found to be detectable. GLP-2 (human) was not found to be detectable. GIP (human) was not found to be detectable.

Legal Information

FEMTOQUEST is a trademark of Merck KGaA, Darmstadt, Germany
SMC is a registered trademark of Singulex
SMCxPRO is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。