- 商品介绍
- 规格参数
- 包装参数
General description
120 kDa (Pezzutto, 1987; Sato, 1997)
CD19 is a 120 kDa transmembrane glycoprotein with a reduced MW of 95 kDa (Pezzutto, 1987; Sato, 1997). CD19 is a member of the immunoglobulin superfamily with two extracellular C2-type domains (Pezzutto, 1987), and it is a critical signal transduction molecule that regulates B lymphocyte development, activation, and differentiation (Sato, 1997). CD19 expression is restricted to B cells, being absent from T cells, monocytes, and granulocytes (Pezzutto, 1987). The CD19 antigen appears early during B cell maturation, probably at late pro-B cell stage around the time of Ig heavy chain rearrangement. It then persists during all stages of B cell maturation and is lost upon terminal differentiation to plasma cells (Pezzutto, 1987).
Immunogen
Hairy cell leukemia cells
Application
Research Category
Inflammation & Immunology
Research Sub Category
Immunoglobulins & Immunology
This Milli-Mark Anti-CD19 -APC Antibody, clone HD37 is validated for use in FC for the detection of CD19 -APC.
Biochem/physiol Actions
Antibody recognizes Human CD19 antigen.
Physical form
Protein A purified
Purified Mouse monoclonal IgG1 conjugated to APC in 0.05M Tris-HCl buffer with 1% BSA, Sodium Azide at 0.097% at pH 7.2
Preparation Note
Maintained refrigerated at 2-8°C from date of receipt. Protected from light in undiluted aliquots for 6 months from date of receipt.
Analysis Note
Control
Human Lymphocytes
Evaluated by flow cytometry using Human Lymphocytes
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Legal Information
MILLI-MARK is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | mouse |
| Quality Segment | 100 |
| conjugate | Allophycocyanin conjugate |
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone | HD37, monoclonal |
| species reactivity | human |
| manufacturer/tradename | Milli-Mark® |
| technique(s) | flow cytometry: suitable |
| isotype | IgG1κ |
| NCBI accession no. | NP_001761.3 |
| UniProt accession no. | P15391 |
| shipped in | wet ice |
| target post-translational modification | unmodified |
| Gene Information | human ... CD19(930) |
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| 重量(kg) |
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