- 商品介绍
- 规格参数
- 包装参数
产品介绍
Product Description
General description
一种细胞可渗透的吡唑并酰胺化合物，以剂量依赖性方式有效阻断TCDD（2，3，7，8-四氯二苯并-对-二恶英）与AhR（芳烃受体）的结合。显示在体外抑制TCDD诱导的HepG2细胞中的AhR转录活性（IC50=30 nM），并在体内预防TCDD引起的小鼠肝毒性和消瘦综合征。与常用的AhR拮抗剂黄酮不同，该抑制剂对雌激素受体的转录活性没有影响，即使在高浓度为10 µM时也没有表现出类似TCDD的激动剂活性。
Biochem/physiol Actions
主要靶标
AhR（芳烃受体）
产物不与ATP竞争。
可逆：否
细胞可渗透性：是
靶标IC50：30 nM，体外阻断TCDD诱导的HepG2细胞AhR转录活性
Packaging
用惰性气体包装
Other Notes
Kim, S.H., et al. 2006.Mol.Pharmacol.69, 1871.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：刺激性（B）
技术参数
Specifications
| Quality Segment | 100 |
| assay | ≥95% (HPLC) |
| form | (Orange-brown) |
| manufacturer/tradename | Calbiochem® |
| storage condition | OK to freeze,protect from light |
| color | orange-brown |
| solubility | DMSO: 10 mg/mL |
| web metadata keyword.default | 2-Methyl-2H-pyrazole-3-carboxylic acid CH-223191,2-Methyl-2H-pyrazole-3-carboxylic acid for liver toxicity research,AhR antagonist CH-223191,AhR antagonist for in vitro studies,AhR antagonist for lab research,AhR antagonist for mouse studies,AhR antagonist for research,AhR antagonist with no estrogen receptor activity,AhR inhibitor for HepG2 cells,CH-223191 AhR antagonist with IC50 30 nM,Sigma-Aldrich CH-223191,TCDD binding blocker CH-223191,cell-permeable pyrazolo-amide compound,high purity CH-223191 AhR antagonist |
| shipped in | ambient |
| storage temp. | 2-8°C |
| SMILES string | [n]1(nccc1C(=O)Nc2c(cc(cc2)\N=N\c3c(cccc3)C)C)C |
| InChI | 1S/C19H19N5O/c1-13-6-4-5-7-17(13)23-22-15-8-9-16(14(2)12-15)21-19(25)18-10-11-20-24(18)3/h4-12H,1-3H3,(H,21,25)/b23-22+ |
| InChI key | LKTNEXPODAWWFM-GHVJWSGMSA-N |
| 长度(mm) | |
| 宽度(mm) | |
| 高度(mm) | |
| 重量(kg) |
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