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Lipoxin A₄, 15-epi，25UG，437725-25UGCN，Sigma

销售价： ¥ 4583.14 / 件

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订货号： 0BV6199

品牌型号： Sigma 437725-25UGCN

货期：询货期

最小订货量： 1件

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商品介绍
规格参数
包装参数

产品介绍 Product Description

General description

A epimeric lipoxin A₄ (Cat. No. 437720) analog that is more potent and metabolically stable than LXA₄. Exhibits anti-inflammatory properties and serves as a "stop signal" to excessive leukocyte trafficking/infiltration. Blocks TNF-α-induced IL-8 release in human enterocyte. It is also an important modulator of the many pharmacological actions caused by aspirin.
An epimeric lipoxin A₄ (Cat. No. 437720) analog that is more potent and metabolically stable than LXA₄. Exhibits anti-inflammatory properties and serves as a "stop signal" to excessive leukocyte trafficking/infiltration. Reported to block TNF-α-induced IL-8 release in human enterocytes. Also reported to be an important modulator of the pharmacological actions of aspirin.

Caution! Product contains volatile liquid; keep cold at all times.
Caution! Product contains volatile liquid. Keep product cold at all times.

Biochem/physiol Actions

Cell permeable: no
Primary Target
Exhibits anti-inflammatory properties
Product does not compete with ATP.
Reversible: no

Packaging

Packaged under inert gas

Physical form

In Ethanol.

Preparation Note

Following initial thaw aliquot and freeze (-70°C).

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Wallace, J.L., and Fiorucci, S. 2003. Trends Pharmacol. Sci.24, 323.
Filep, J.G., et al. 2002. Adv. Exp. Med. Biol.507, 223.
Titos, E., et al. 1999. Am. J. Physiol.277, C870.
Gronert, K., et al. 1998. J. Exp. Med.187, 1285.
Maddox, J.F., et al. 1997. J. Biol. Chem.272, 6972.
Claria, J., et al. 1996. Mol. Med.2, 583.
Claria, J., and Serhan, C.N. 1995. Proc. Natl. Acad. Sci. USA92, 9475.
Serhan, C.N., et al. 1995. Biochemistry34, 14609.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Flammable (J)

技术参数 Specifications

Quality Segment	100
assay	≥98% (HPLC)
form	liquid
manufacturer/tradename	Calbiochem^®
storage condition	OK to freeze,desiccated (hygroscopic),protect from light
shipped in	wet ice
storage temp.	−70°C
SMILES string	OC(C(O)\C=C\C=C\C=C\C=C\C(O)CCCCC)CCCC(=O)O
InChI	1S/C20H32O5/c1-2-3-8-12-17(21)13-9-6-4-5-7-10-14-18(22)19(23)15-11-16-20(24)25/h4-7,9-10,13-14,17-19,21-23H,2-3,8,11-12,15-16H2,1H3,(H,24,25)/b6-4+,7-5+,13-9+,14-10+
InChI key	IXAQOQZEOGMIQS-CRSXNMAESA-N

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