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AG 490，5MG，658401-5MGCN，Sigma

销售价： ¥ 707.92 / 件

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订货号： 0BV6100

品牌型号： Sigma 658401-5MGCN

货期：询货期

最小订货量： 1件

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商品介绍
规格参数
包装参数

产品介绍 Product Description

General description

A cell-permeable, reversible, substrate competitive, and potent inhibitor of epidermal growth factor receptor kinase autophosphorylation (IC₅₀ = 100 nM). Inhibition of JAK2 by AG 490 selectively blocks leukemic cell growth in vitro and in vivo by inducing programmed cell death, with no harmful effect on normal hematopoiesis. Inhibits the constitutive activation of STAT-3 DNA binding and IL-2-induced growth of MF tumor cells. AG 490 has also been shown to inhibit the autokinase activity of JAK3. A 100 mM (5 mg/170 µl) solution of AG490 (Cat. No. 658411) in DMSO is also available.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
epidermal growth factor receptor kinase autophosphorylation
Product does not compete with ATP.
Reversible: yes
Target IC₅₀: 100 nM against epidermal growth factor receptor kinase autophosphorylation

Preparation Note

Following reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 6 months at -70°C.

Other Notes

Jaleel, M., et al. 2004. Biochemistry43, 8247.
Eriksen, K.W., et al. 2001. Leukemia15, 787.
Kirken, R.A., et al. 1999. Leukoc. Biol.65, 891.
Nielsen, M., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 6764.
Meydan, N., et al. 1996. Nature 379, 645.
Gazit, A., et al. 1991. J. Med. Chem.34, 1896.
Levitzki, A. 1990. Biochem. Pharmacol.40, 913.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

技术参数 Specifications

Quality Segment	100
assay	≥98% (HPLC)
form	solid
manufacturer/tradename	Calbiochem^®
storage condition	OK to freeze,protect from light
color	yellow
solubility	DMSO: 100 mg/mL
web metadata keyword.default	100 nM AG 490 potency,AG 490 IL-2 induced growth blocker,AG 490 JAK2 inhibitor 100 nM,AG 490 JAK3 inhibitor XI,AG 490 STAT-3 DNA binding inhibitor,AG 490 alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide,AG 490 cell-permeable inhibitor,AG 490 epidermal growth factor receptor kinase inhibitor,AG 490 for leukemic cell growth inhibition,AG 490 for programmed cell death research,AG 490 laboratory-grade inhibitor,AG 490 titration reagent,AG 490,reversible JAK2 inhibitor AG 490
shipped in	ambient
storage temp.	−20°C
SMILES string	N(Cc2ccccc2)C(=O)\C(=C\c1cc(c(cc1)O)O)\C#N
InChI	1S/C17H14N2O3/c18-10-14(8-13-6-7-15(20)16(21)9-13)17(22)19-11-12-4-2-1-3-5-12/h1-9,20-21H,11H2,(H,19,22)/b14-8+
InChI key	TUCIOBMMDDOEMM-RIYZIHGNSA-N

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