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KN-93，5MG，422708-5MGCN，Sigma

销售价： ¥ 8417.90 / 件

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订货号： 0BV5307

品牌型号： Sigma 422708-5MGCN

货期：询货期

最小订货量： 1件

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商品介绍
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包装参数

产品介绍 Product Description

General description

A cell-permeable, reversible and competitive inhibitor of rat brain CaM kinase II (K_i = 370 nM). Selectively binds to the CaM binding site of the enzyme and prevents the association of CaM with CaMKII. Has no significant effects on protein kinase A activity. Induces G₁ cell cycle arrest and apoptosis in NIH/3T3 cells. A 5 mM (1 mg/399 µl) solution of KN-93 (Cat. No. 422712) in DMSO is also available.
Cell-permeable, reversible, and competitive inhibitor of rat brain Ca⁺²/calmodulin-dependent protein kinase II (K_i = 370 nM). KN-93 selectively binds to the Calmodulin (CaM) binding site of the enzyme and prevents the association of CaM with CaM Kinase II. Selectively binds to the CaM binding site of the enzyme and prevents the association of CaM with CaMKII. Has no significant effect on protein kinase A activity. Induces G₁ cell cycle arrest and apoptosis in NIH 3T3 cells.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
cam kinase 2
Product competes with ATP.
Reversible: yes
Target K_i: 370 nM against rat brain CaM kinase II

Preparation Note

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.

Other Notes

Fan, G.H., et al. 1999. Mol. Pharmacol.56, 39.
Tombes, R.M., et al. 1995. Cell Growth Differ.6, 1063.
Mamiya, N., et al. 1993. Biochem. Biophys. Res. Commun. 195, 608.
Nicki, I., et al. 1993. Biochem. Biophys. Res. Commun.191, 255.
Sumi, M., et al. 1991. Biochem. Biophys. Res. Commun.181, 968.
Tokumitsu, H., et al. 1990. J. Biol. Chem.265, 4315.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

技术参数 Specifications

Quality Segment	100
assay	≥95% (HPLC)
form	solid
manufacturer/tradename	Calbiochem^®
storage condition	OK to freeze,protect from light
color	off-white
solubility	DMSO: 5 mg/mL
shipped in	ambient
storage temp.	2-8°C
SMILES string	[S](=O)(=O)(N(CCO)c2c(cccc2)CN(C\C=C\c3ccc(cc3)Cl)C)c1ccc(cc1)OC
InChI	1S/C26H29ClN2O4S/c1-28(17-5-6-21-9-11-23(27)12-10-21)20-22-7-3-4-8-26(22)29(18-19-30)34(31,32)25-15-13-24(33-2)14-16-25/h3-16,30H,17-20H2,1-2H3/b6-5+
InChI key	LLLQTDSSHZREGW-AATRIKPKSA-N

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