- 商品介绍
- 规格参数
- 包装参数
General description
17kDa
Histone H3 is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N-terminal tail, H3 is involved with the structure of the nucleosomes of the ′beads on a string′ structure.
The N-terminal tail of histone H3 protrudes from the globular nucleosome core and can undergo several different types of epigenetic modifications that influence cellular processes. These modifications include the covalent attachment of methyl or acetyl groups to lysine and arginine amino acids and the phosphorylation of serine or threonine.
Immunogen
A proprietary immunogen based on a peptide sequence containing phospho-serine corresponding to residue 10 of human histone H3, clone 3H10. This is a Cy5 conjugate of Anti-phospho-Histone H3 (Ser10), clone 3H10, Catalog # 05-806.
Application
Anti-Phospho-Histone H3 (Ser10) Antibody, clone 3H10, Cy5 Conjugate is a Mouse Monoclonal Antibody for detection of Histone H3 phosphorylated at serine 10. This purified mAb, also known as H3S10p,
is labeled with Cy5.5 NHS ester (Cy5) and validated in IF, WB.
Research Category
Epigenetics & Nuclear Function
Research Sub Category
Histones
Biochem/physiol Actions
Expected to cross react with all vertebrate species.
Histone H3 phosphorylated at Ser10
Physical form
Protein G Purified
Preparation Note
1 year at 4°C from date of shipment
Analysis Note
Control
Acid extracts from colcemid treated HeLa cells (lane 2)
Routinely evaluated by immunoblot in acid extrated protein from mitotic HeLa cells treated with colcemid (17-306).
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | mouse |
| Quality Segment | 100 |
| conjugate | CY5 conjugate |
| antibody form | purified antibody |
| antibody product type | primary antibodies |
| clone | 3H11, monoclonal |
| species reactivity | human |
| manufacturer/tradename | Upstate® |
| technique(s) | immunofluorescence: suitable,western blot: suitable |
| isotype | IgG1κ |
| NCBI accession no. | NM_003493.2 |
| UniProt accession no. | Q16695 |
| shipped in | wet ice |
| target post-translational modification | phosphorylation (pSer10) |
| Gene Information | human ... HIST1H3F(8968) |
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¥ 1302.89
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