MDM2 Antagonist, Nutlin-3, Racemic，1MG，444143-1MGCN，Sigma 供应商、价格、厂家、报价、规格参数

产品介绍 Product Description

General description

A cell-permeable cis-imidazoline compound that acts as a potent and selective MDM2 antagonist (IC₅₀ = 90 nM for Nutlin-3a and 13.6 µM for Nutlin-3b) and displays antitumor properties. Activates p53 pathway by binding MDM2 in the p53-binding pocket and inhibits MDM2-p53 interaction. Shown to suppress tumor growth by induction of apoptosis in several cancer cells with wild-type p53 and in xenografted tumor mice. A 10 mM (1 mg/172 µl) solution of MDM2 Antagonist, Nutlin-3, Racemic (Cat. No. 444151) in DMSO is also available.
A cell-permeable, potent, and selective MDM2 antagonist (IC₅₀ = 90 nM for Nutlin-3a and 13.6 µM for Nutlin-3b) that displays antitumor properties. Activates the p53 pathway by binding MDM2 in the p53-binding pocket and inhibiting the MDM2-p53 interaction. Shown to induce apoptosis in several cancer cell lines with wild-type p53 and in xenografted tumor mice.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
MDM2
Product does not compete with ATP.
Reversible: no
Target IC₅₀: 90 nM for Nutlin-3a and 13.6 µM for Nutlin-3b

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot, purge with inert gas, and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Thompson, T., et al. 2004. J. Biol. Chem.279, 53015.
Vassilev, L.T., et al. 2004. Science303, 844.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful (C)

技术参数 Specifications

Quality Segment	100
assay	≥98% (TLC and HPLC)
form	solid
manufacturer/tradename	Calbiochem^®
storage condition	OK to freeze,protect from light
solubility	DMSO: 25 mg/mL,ethanol: 25 mg/mL
shipped in	wet ice
storage temp.	−20°C
SMILES string	Clc1ccc(cc1)C2N(C(=NC2c5ccc(cc5)Cl)c4c(cc(cc4)OC)OC(C)C)C(=O)N3CCNC(=O)C3
InChI	1S/C30H30Cl2N4O4/c1-18(2)40-25-16-23(39-3)12-13-24(25)29-34-27(19-4-8-21(31)9-5-19)28(20-6-10-22(32)11-7-20)36(29)30(38)35-15-14-33-26(37)17-35/h4-13,16,18,27-28H,14-15,17H2,1-3H3,(H,33,37)
InChI key	BDUHCSBCVGXTJM-UHFFFAOYSA-N

长度(mm)
宽度(mm)
高度(mm)
重量(kg)