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General description
Deposits of amyloid protein in senile plaques near nerve processes are found in the brains of aged humand and cases of Alzheimer′s Disease. The principle component of this extracellular amyloid is beta/A4, a 4 kDa peptide derived from a larger amyloid precursor protein (APP), which is widely expressed in the brain and body. The creation, transport and function of these proteins are currently under investigation Reacts with pre-A4.
Immunogen
Epitope: a.a. 66-81 (N-terminus), Prediluted
Purified recombinant Alzheimer precursor A4 (pre A4695) fusion protein.
Application
Antibody is prediluted and ready to use for Immunohistochemistry of formalin-fixed, paraffin-embedded tissues.
Pretreatment: Heat Induced Epitope Retrieval (HIER). Recommend Citrate Buffer, pH 6.0 (Cat. No. 21545). No signal was detected without Epitope retrieval.
Incubation: 30 minutes with IHC Select
App has been prediluted for use as the primary antibody with Chemicon′s IHC Select
Detect Alzheimer Precursor Protein A4 using this Anti-APP A4 Antibody, a.a. 66-81 (N-terminus), Prediluted, clone 22C11 validated for use in IH(P).
Research Category
Neuroscience
Research Sub Category
Neurodegenerative Diseases
Biochem/physiol Actions
The antibody recognizes amino acids 66-81 of the N-terminus on the pre-A4 molecule (Hilbich et al., 1993). 22C11 recognizes all three isoforms of APP, immature ~110kDa, sAPP ~120kDa, and mature ~130kDa (Hoffmann et al., 2000). The antibody is known to cross react with APLP2 (Slunt, 1994).
Physical form
Format: Purified
Liquid diluted in PBS, pH 7.2 with stabilizers, 0.2% Tween 20, and 0.1% preservative.
Preparation Note
Maintain at 2-8°C. Refer to vial for expiration dating.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | mouse |
| Quality Segment | 100 |
| antibody product type | primary antibodies |
| clone | 22C11, monoclonal |
| species reactivity | canine, mouse, monkey, pig, fish, human, rat |
| manufacturer/tradename | Chemicon® |
| technique(s) | immunohistochemistry: suitable (paraffin) |
| isotype | IgG1 |
| NCBI accession no. | NM_000484.2,NM_201413.1,NM_201414.1 |
| UniProt accession no. | P05067 |
| shipped in | wet ice |
| target post-translational modification | unmodified |
| Gene Information | human ... APP(351) |
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