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- 规格参数
- 包装参数
General description
LRP1 (low density receptor protein 1) gene codes for a protein belonging to LDL receptor family. Lrp1 is known to be the largest mammalian endocytic receptor. The encoded protein is cysteine-rich and it is highly glycosylated. It is predominantly expressed in vascular smooth muscle cells, neurons, astrocytes, macrophages, hepatocytes, fibroblasts and malignant cells. The LDLRs (low-density lipoprotein receptors) have five domains namely repeated cysteine-rich regions of ligand-binding type and epidermal growth factor receptor-like repeats, YWTD (tyrosin, typrtophan, Threonine, aspartic) domains, a transmembrane domain, and a cytoplasmic tail that holds about three NPXY (asparagine-proline-X-tyrosine) motifs.
Immunogen
LRP1 (4520-4554)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human LRP1.
Biochem/physiol Actions
LRP1 functions as a scavenger by internalizing several plasma components and also serves as a signaling molecule. Lrp1 is responsible for the transport of β-amyloid (Aβ) across the blood brain barrier, thereby contributing to the pathogenesis of Alzheimer′s disease. Lrp1 is normally associated with the cell membrane, but proteolytic cleavage of the cell results in its soluble form. Therefore, it loses its ability to endocytose and transport ligands. LRP1 is associated with a number of signaling pathways, such as mitogen-activated protein kinase (MAPK), serine/threonine protein kinase (AKT), insulin receptor (IR), extracellular signal-regulated kinase (ERK), and c-jun N-terminal kinase (JNK) pathways.
Physical form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
| biological source | rabbit |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | buffered aqueous solution |
| species reactivity | human |
| technique(s) | immunohistochemistry: 1:50-1:100,indirect ELISA: 1:1000 |
| NCBI accession no. | NP_002323 |
| UniProt accession no. | Q07954 |
| shipped in | dry ice |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| Gene Information | human ... LRP1(4035) |
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¥ 503.76
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¥ 3254.04
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¥ 627.44
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¥ 1608.31
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¥ 4274.19
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¥ 1155.55
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¥ 1464.96
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¥ 26022.64
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¥ 29754.56
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