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Biochem/physiol Actions
Cell penetrant, potent and elective allosteric activator of glutathione peroxidase 4 (GPX4) that potently inhibit ferroptosis.
GPX4-Activator-1d4 HCl is a cell penetrant, potent and elective allosteric activator of glutathione peroxidase 4 (GPX4) that potently inhibit ferroptosis. It significantly increases GPX4 activity to 150% at 20 μM in the cell-free assay and 61 μM in cell extracts. GPX4-Activator-1d4 suppresses ferroptosis and inflammation in HT-1080 fibrosarcoma cells.
Disclaimer
Hygroscopic
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| storage condition | desiccated |
| color | white to beige |
| solubility | H2O: 2 mg/mL, clear |
| storage temp. | -10 to -25°C |
| SMILES string | S=C(NC1=CC=C(C=C1)S(NCCN)(=O)=O)NC2CCCC2.Cl |
| InChI key | FELDRJSFLBINQS-UHFFFAOYSA-N |
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¥ 1259.40
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¥ 2068.25
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¥ 3109.49
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¥ 9737.84
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¥ 1568.60
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