- 商品介绍
- 规格参数
- 包装参数
Biochem/physiol Actions
Selective α-synuclein (α-syn) translation inhibitor with cytoprotective efficacy against preformed α-syn fibrils (PFFs) in SH-SY5Y neuronal cultures.
Synucleozid is a selective α-synuclein (α-syn) translation inhibitor (46% & 69% α-syn downregulation post 48 h, respectively, with 0.5 or 1 μM Synucleozid) with cytoprotective efficacy against preformed α-synuclein fibrils (PFFs) in SH-SY5Y neuronal cultures (56% protection; 0.5 μM Synucleozid added 24 h prior to 48 h 50 μg/mL PFFs exposure). Synucleozid directly and selectively targets α-syn (SNCA) mRNA 5′ UTR at the iron-responsive element (IRE) site, effectively interfering with the polysomes assembly onto SNCA mRNA.
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| storage condition | desiccated |
| color | , White to very dark grey |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | 2-8°C |
| SMILES string | [nH]1c2c(cc1c3ccc(cc3)Nc4ccc(cc4)C(=N)N)ccc(c2)C(=N)N |
| InChI | 1S/C22H20N6/c23-21(24)14-5-9-18(10-6-14)27-17-7-3-13(4-8-17)19-11-15-1-2-16(22(25)26)12-20(15)28-19/h1-12,27-28H,(H3,23,24)(H3,25,26) |
| InChI key | TZRXNWCLKYWDNH-UHFFFAOYSA-N |
| 长度(mm) | |
| 宽度(mm) | |
| 高度(mm) | |
| 重量(kg) |
-
询价
-
询价
-
询价
-
¥ 8520.40
-
¥ 9737.84
-
询价
-
询价
-
¥ 3372.68
-
¥ 3290.05
-
瓶顶过滤器-500ml容量,MF75TM系列，聚苯乙烯外壳，75mmPES滤膜，孔径0.45um,适合瓶颈尺寸33mm，12/箱，295-3345，Nalgene，Thermofisher，赛默飞世尔¥ 1938.54
-
询价
-
询价
-
¥ 2842.54
-
¥ 8137.12
-
¥ 4476.05
-
¥ 5426.00
-
询价
-
询价
-
¥ 165230.53
-
¥ 26846.31
微信小程序
7X24小时在线咨询