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General description
Tumor susceptibility gene 101 (TSG101) is an endosomal sorting complex required for transport (ESCRT) component, present on endosomal membranes. This gene is located on chromosome 11p15. The TSG101 gene encodes a 46 kDa protein and contains a proline-rich domain and a leucine-zipper motif within a coiled-coil domain near the carboxyl terminus.
Immunogen
Amino acids 167-374 of TSG101 protein expressed in E. coli.
Application
Suggested starting dilutions are as follows: WB: 1:500-1:3000. Suggested fixation for ICC/IF: 3-3.5% PFA with 0.05% saponin treatment. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.
Monoclonal Anti-TSG101 antibody has been used in western blotting and immunoprecipitation (IP) analyses.
Biochem/physiol Actions
The TSG101 gene encodes a 46 kDa protein and contains a proline-rich domain and a luecine-zipper motif within a coiled-coil domain near the carboxyl terminus.
Tumor susceptibility gene 101 (TSG101) is essential for the generation of central supramolecular activation cluster, and the signal termination of T cell receptor (TCR) microclusters (MC). It plays an important role in TCR downregulation and separation of TCR- major histocompatibility complex (MHC)-peptide from signaling complexes, that are enriched with protein kinase C θ (PKCθ).
TSG101-4A10 recognizes TSG101 protein, the product of a recently identified tumor susceptibility gene whose inactivation in mouse fibroblasts results in cell transformation and the ability of those cells to form tumors in nude mice.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Phosphate-buffered saline, no preservative added.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | mouse |
| Quality Level | 100 |
| conjugate | unconjugated |
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone | 4A10,monoclonal |
| form | liquid |
| mol wt | 46 kDa |
| species reactivity | human, monkey, mouse, rat, hamster |
| concentration | 1 mg/mL |
| technique(s) | ELISA: suitable,flow cytometry: suitable,immunocytochemistry: suitable,immunofluorescence: suitable,immunohistochemistry: suitable,immunoprecipitation (IP): suitable,western blot: 1:500-1:3000 |
| isotype | IgG1 |
| UniProt accession no. | Q99816 |
| shipped in | wet ice |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| Gene Information | human ... TSG101(7251) |
| 长度(mm) | |
| 宽度(mm) | |
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