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Biochem/physiol Actions
G-quadruplex ligand that potently induces significant telomere-associated DNA damage in cancer cells
Pt-ttpy, a metallo-organic complex, is a G-quadruplex ligand that potently induces significant telomere-associated DNA damage in cancer cells. It inhibits telomerase and/or telomere functions. Pt-ttpy induces number of chromatin defects in mitosis including chromatin bridges, ultrafine bridges (UFBs), and double-stranded breaks (DSBs).
| assay | >97% (NMR) |
| form | powder |
| color | faint yellow to dark orange |
| solubility | DMSO: 0.2 mg/mL (warmed) |
| storage temp. | 2-8°C |
| SMILES string | CC1=CC=C(C2=CC(C3=[N+]4C=CC=C3)=[N+]5C(C6=CC=CC=[N+]6[Pt-2]54Cl)=C2)C=C1.[Cl-] |
| InChI | 1S/C22H17N3.2ClH.Pt/c1-16-8-10-17(11-9-16)18-14-21(19-6-2-4-12-23-19)25-22(15-18)20-7-3-5-13-24-20;;;/h2-15H,1H3;2*1H;/q;;;+2/p-2 |
| InChI key | UWAUJHRZLKCPPX-UHFFFAOYSA-L |
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¥ 15214.65
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