- 商品介绍
- 规格参数
- 包装参数
Application
STF-31 has been used in glucose transporter 1 (GLUT1) inhibition.
Biochem/physiol Actions
STF-31 selectively inhibits the glucose transporter GLUT1.
STF-31 selectively inhibits the glucose transporter GLUT1 and selectively impairs cancer cell growth of kidney and other types of cancer cells that lack the von Hippel-Lindau (VHL) tumor suppressor protein. Inactivation of VHL increases the activity of hypoxia-inducible factor transcription factor HIF, which in turn stimulates the transcription of genes involved in glucose metabolism, including the GLUT1 gene. VHL-deficient cancer cells, which include about 80% of renal cell carcinomas, are dependent on the high affinity GLUT1 transporter and aerobic glycolysis for ATP production. STF-31 binds directly to the GLUT1 transporter, blocking glucose uptake, resulting in necrosis in VHL-deficient cancer cells, but not in normal cells or cancer cells with intact VHL.
Features and Benefits
This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 20 mg/mL, clear |
| storage temp. | −20°C |
| SMILES string | O=C(NC1=CN=CC=C1)C2=CC=C(CNS(=O)(C3=CC=C(C(C)(C)C)C=C3)=O)C=C2 |
| InChI | 1S/C23H25N3O3S/c1-23(2,3)19-10-12-21(13-11-19)30(28,29)25-15-17-6-8-18(9-7-17)22(27)26-20-5-4-14-24-16-20/h4-14,16,25H,15H2,1-3H3,(H,26,27) |
| InChI key | NGQPRVWTFNBUHA-UHFFFAOYSA-N |
| 长度(mm) | |
| 宽度(mm) | |
| 高度(mm) | |
| 重量(kg) |
-
询价
-
询价
-
询价
-
¥ 3152.47
-
询价
-
¥ 6330.00
-
询价
-
¥ 14407.09
-
¥ 20380.83
-
¥ 4020.77
-
¥ 1783.21
-
¥ 2132.12
-
¥ 3031.24
-
¥ 2288.54
-
¥ 26022.64
-
¥ 15537.49
-
¥ 29754.56
-
¥ 3704.60
-
¥ 390328.90
-
¥ 1799.83
微信小程序
7X24小时在线咨询