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雷尼酸锶，10MG，SML0596-10MG，Sigma

销售价： ¥ 612.03 / 件

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订货号： 0BT9297

品牌型号： Sigma SML0596-10MG

货期：询货期

最小订货量： 1件

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产品介绍 Product Description

Biochem/physiol Actions

Strontium ranelate is a dual action bone agent (DABA). It inhibits bone resorption and stimulates bone formation, inhibiting osteoclast differentiation while activating gene expression in osteoblasts. While its exact mechanism of action is unknown, one hypothesis is that both anabolic and anti-catabolic activities may involve antagonizing nuclear factor-KB (NF-KB) activation in bone cells. Strontium ranelate has been shown to inhibit the receptor activator of NF-KB ligand (RANKL)-induced nuclear translocation of NF-KB and activator protein-1. Strontium ranelate has been used clinically for the treatment of osteoporosis and a recent multinational study indicates the drug can also be used to treat osteoarthritis.
Strontium ranelate is a dual action bone agent (DABA); inhibitor of bone resorption and stimulator of bone formation.

Features and Benefits

This compound is featured on the Cytokine Receptors (Tumor Necrosis Receptor Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

技术参数 Specifications

Quality Segment	100
assay	≥98% (HPLC)
form	powder
color	white to beige
solubility	H₂O: 1 mg/mL, clear (warmed)
storage temp.	−20°C
SMILES string	[Sr+2].[Sr+2].[s]1c(c(c(c1C(=O)[O-])CC(=O)[O-])C#N)N(CC(=O)[O-])CC(=O)[O-]
InChI	1S/C12H10N2O8S.2Sr/c13-2-6-5(1-7(15)16)10(12(21)22)23-11(6)14(3-8(17)18)4-9(19)20;;/h1,3-4H2,(H,15,16)(H,17,18)(H,19,20)(H,21,22);;/q;2*+2/p-4
InChI key	XXUZFRDUEGQHOV-UHFFFAOYSA-J

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