- 商品介绍
- 规格参数
- 包装参数
Application
BI-2865 may be used for studying the Kirsten rat sarcoma virus (KRAS)signaling pathways and their role in cancer. Its selective inhibition of KRAS isused to probe the biological functions of KRAS, its mutants, and downstreamsignaling pathways to gain a deeper understanding of KRAS-related oncogenesis.
Biochem/physiol Actions
BI-2865 is a cell penetrant, selective and potent pan-KRAS inhibitor, which binds with high affinity to the inactive state of KRAS and KRAS mutants. BI-2865 blocks nucleotide exchange to prevent the activation of wild-type KRAS and a broad range of KRAS mutants. It inhibits downstream signaling and growth in cancer cells harboring mutant KRAS. It does not bind to NRAS and HRAS.
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | -10 to -25°C |
| SMILES string | NC(S1)=C(C#N)C2=C1CCC[C@]2(C)C3=NC(C4=NC(O[C@@H](C)[C@]5([H])CCCN5C)=CC=N4)=NO3 |
| 长度(mm) | |
| 宽度(mm) | |
| 高度(mm) | |
| 重量(kg) |
-
询价
-
¥ 503.76
-
¥ 1243.80
-
询价
-
询价
-
询价
-
询价
-
询价
-
¥ 782.57
-
询价
-
¥ 1756.15
-
询价
-
¥ 907.59
-
¥ 633.78
-
¥ 502.32
-
¥ 852.85
-
¥ 1212.50
-
¥ 2321.98
-
¥ 915.42
-
¥ 66743.99
微信小程序
7X24小时在线咨询