IL-15 human,10UG,SRP3077-10UG,Sigma

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订货号 0BT2517
品牌型号 Sigma SRP3077-10UG
货期 询货期
最小订货量 1件
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  • 商品介绍
  • 规格参数
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产品介绍 Product Description

General description

Interleukin-15 (IL-15) is an immunomodulating cytokine. The gene encoding it is localized on chromosome 4q31. Human IL-15 is biologically active on mouse cells as measured by the dose-dependent stimulation of the proliferation of mouse CTLL cells. Recombinant human IL-15 is a 12.9kDa protein consisting of 115 amino acid residues.


Biochem/physiol Actions

Interleukin-15 (IL-15) stimulates the proliferation of T lymphocytes and shares many biological properties with IL-2. It exerts its biological activities primarily on T cells. It is also essential in the development, survival and activation of NK cells. On binding to its receptor, IL-15 is indirectly involved in activating proto-oncogenes. Increased expression of IL-15 has been implicated with rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis and diseases affiliated with retroviruses like human immunodeficiency virus (HIV) and human T-lymphotropic virus-1 (HTLV-I).


Physical form

Lyophilized from 10 mM Sodium Phosphate, pH 8.5.


Preparation Note

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a stabilizer (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.


Other Notes

MNWVNVISDL KKIEDLIQSM HIDATLYTES DVHPSCKVTA MKCFLLELQV ISLESGDASI HDTVENLIIL ANNSLSSNGN VTESGCKECE ELEEKNIKEF LQSFVHIVQM FINTS


技术参数 Specifications
biological sourcehuman
recombinantexpressed in E. coli
assay≥98% (HPLC),≥98% (SDS-PAGE)
formlyophilized
potency≤0.5 ng/mL ED50
mol wt 12.9 kDa
packagingpkg of 10 μg
technique(s)cell culture | mammalian: suitable
impurities<0.1 EU/μg endotoxin, tested
color white to off-white
UniProt accession no.P40933
shipped inwet ice
storage temp.−20°C
Gene Informationhuman ... IL15(3600)
长度(mm)
宽度(mm)
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重量(kg)
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