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General description
Dimethyl N-oxalyl-D-phenylalanine (DM-NOFD) is a small FIH (factor-inhibiting) inhibitor molecule.
Biochem/physiol Actions
DM-NOFD is a cell penetrant, prodrug of NOFD a potent and selective inhibitor of an asparaginyl hydroxylase FIH (factor-inhibiting HIF).
DM-NOFD is a cell penetrant, prodrug of NOFD a potent and selective inhibitor of an asparaginyl hydroxylase FIH (factor-inhibiting HIF). DM-NOFD efficiently reduces HIF1a CAD (C-terminal activating domain) hydroxylation in MCF-7 cells.
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | oil |
| color | , colorless to dark yellow |
| storage temp. | 2-8°C |
| SMILES string | O=C(C(N[C@H](CC1=CC=CC=C1)C(OC)=O)=O)OC |
| InChI | 1S/C13H15NO5/c1-18-12(16)10(14-11(15)13(17)19-2)8-9-6-4-3-5-7-9/h3-7,10H,8H2,1-2H3,(H,14,15)/t10-/m1/s1 |
| InChI key | CAUUPQLNYYFMOQ-SNVBAGLBSA-N |
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