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General description
This gene encodes a serine/threonine protein kinase activated by proapoptotic molecules indicating the encoded protein functions as a growth suppressor. Cleavage of the protein product by caspase removes the inhibitory C-terminal portion. The N-terminal portion is transported to the nucleus where it homodimerizes to form the active kinase which promotes the condensation of chromatin during apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Immunogen
A phospho specific peptide corresponding to residues surrounding T180/T183 of human STK3/STK4.
Physical form
Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
| biological source | rabbit |
| Quality Segment | 100 |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | liquid |
| species reactivity | mouse, rat, human |
| concentration | 1.46 mg/mL |
| technique(s) | western blot: 1:500-1:2000 |
| UniProt accession no. | Q13188/Q13043 |
| shipped in | wet ice |
| storage temp. | −20°C |
| target post-translational modification | phosphorylation (pThr180/pThr183) |
| 长度(mm) | |
| 宽度(mm) | |
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| 重量(kg) |
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