- 商品介绍
- 规格参数
- 包装参数
Application
TED-37 is used to probe the how dyregulation ofYAP-TEAD signalling relates to glioblastoma proliferations.
Biochem/physiol Actions
TED-347is a potent and selective allosteric inhibitor of the transcriptional enhanced associate domain (TEAD)-yes-associated protein 1 (Yap1) protein-protein interaction (EC50 =5.9 µM) that inhibits TEAD transcriptional activity. It potentlyinhibits growth of spheroids of patient-derived GBM43 glioblastoma cell lines.TED-347 binds to the TEAD4 palmitate pocket where it forms covalent bond withCys-367.
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | -10 to -25°C |
| SMILES string | O=C(C1=CC=CC=C1NC2=CC(C(F)(F)F)=CC=C2)CCl |
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¥ 638.71
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¥ 625.35
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¥ 1153.44
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¥ 1761.75
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¥ 656.88
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¥ 699.66
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¥ 2005.84
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¥ 70526.15
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